A silver color metal and enamel device 1 1/8 inches (2.86 cm) in height overall consisting of a white chevron above four water oak leaves and surmounted by a fitchee cross bearing a heraldic fountain.

Maroon and white are the colors used for the Army Medical Department. The fountain is symbolic of healing and continued renewal; the chevron represents accomplishment; the cross identifies the unit as a medical organization. The chevron and fountain also allude to the organization's participation in the Ryukyus Island campaign during World War II. The chevron's simulation of an "A" refers to Alabama, the unit's present location. The oak leaves symbolize the city of Tuscaloosa, known as the "City of the Oaks," where the organization is located. The oak leaves also refer to the Roman practice of awarding an oak leaf crown to one who saved a soldier's life.

The distinctive unit insignia was originally approved for the 75th Field Hospital on 18 March 1971. It was redesignated for the 75th Combat Support Hospital with the description and symbolism revised on 15 July 1994. The unit was redesignated back to the 75^th Field Hospital on 16 September 2019.